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The company was founded in 1999 through the merger of the Swedish Astra AB and it has made numerous corporate acquisitions, including Cambridge Antibody Technology, MedImmune, Spirogen and Definiens. AstraZeneca has a listing on the London Stock Exchange and is a constituent of the FTSE100 Index. It has secondary listings on the New York Stock Exchange and the OMX exchange, Astra AB was founded in 1913 in SĂdertĂlje, Sweden, by 400 doctors and apothecaries.

While there is no widespread definition adopted by all demographic researchers, premature death and premature mortality are terms generally referring to a death which occurs prior to the average life expectancy for a given population. Depending on the standard of public health in a country, the threshold age considered to be "premature" would differ. For example, the US Centers for Disease Control and Prevention (CDC) describe a death before the age of 80 as premature in documents such as the Morbidity and Mortality Weekly Report. In high income nations, death rates for middle-aged adults have declined dramatically since the 1970s, thanks to more people quitting smoking and better survival rates after heart attack and stroke. Even better for those living in industrialized countries, notes epidemiologist and international public health researcher Prabhat Jha, health promotion strategies including better secondary treatment after a cardiovascular event, more effective diabetes control and anti-smoking campaigns have helped compress morbidity - meaning the onset of many age-related diseases is delayed until a person is older, and they stay healthier, longer.

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