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Thomas Bodenheimer mentions, without providing a source, that a single day's delay in getting a drug to market costs 1. 3 million [12]. Claims associated with costs of drug development merit careful scrutiny since they are often used as a rhetorical tool to argue for faster approval times or to justify the high price of pharmaceuticals. However, it is fair to presume that delays have financial repercussions. At a 2003 conference, Neil Maresky, vice president of scientific affairs at Wyeth, stated that problems in patient recruitment are ¬the biggest delaying factor in clinical trials¬ [14].

If in terms of core substance use outcomes, cognitive-behavioural therapy in methadone maintenance does little to improve on routine counselling, this will simply be in line with findings in respect of the therapy8217;s role in treating drug and alcohol problems in general. A review combining results from relevant studies suggested that it remains to be shown that cognitive-behavioural therapies are more effective than other similarly extensive and coherent approaches.]