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In this study, researchers examined the effects of methadone on oligodendrocytes during development in an animal model. Rat pups were exposed to methadone both through the placenta and through maternal milk until postnatal day 14, a period that is equivalent to the third trimester in human pregnancy. The researchers found that therapeutic doses of methadone caused increases in multiple proteins found in myelin and an increase in number of neurons with mature myelin.

Political Science, International Relations, and Public Policy Section 4, archaeology, Anthropology, Sociology, Geography and Demography Class IV Arts and Humanities Section 1. National Academy of Sciences The National Academy of Sciences is a United States nonprofit, non-governmental organization.]