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¬The introduction of buprenorphine, a new medication to treat opioid dependence that has fewer restrictions than methadone, holds promise for reducing HIV transmission and improving the care of patients with opioid dependence and HIV disease,‚ write the review‚s authors, Lynn Sullivan and David Fiellin from Yale University School of Medicine. ‚Methadone has a long history of proven efficacy and benefits in treating opioid dependence, and the addition of buprenorphine serves to expand the treatment options‚. Buprenorphine has become more widely available over the last ten years, and is available alone or in combination with naloxone, a drug that blocks the mu-opioid receptor.

When it comes to addiction, opioids are an off-switch for an off-switch. Opioids hold back GABAergic neurons in the midbrain, which in turn keep another neurotransmitter called dopamine from flooding a brain‚s pleasure circuits. Image by Adam Sarraf. Once opioids shut off GABAergic neurons, the pleasure circuits fill with another neurotransmitter called dopamine.

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